With tourism being so important to the economy there are usually plenty of options to chose from.Examples would include:
Caravan sites. Typically farm based. A good example being Mains farm caravan site, Kirkoswald. (http://www.edenvalleycara...) examples could also include Argill caravan park,Kirkby Stephen. (http://www.argillcaravanp...)
Hotels.At the upper end of the market there are some fine country house hotels such as the Appleby Manor (http://www.applebymanor.co.uk/), the Tufton Arms Hotel (http://www.tuftonarmshote...) and Staffield Hall, near the village of Kirkoswold, (http://www.staffieldhall.co.uk). A little further down the valley there is the Heather Glen hotel at Ainstable and the Crown hotel at Wetherall.
For self catering there are a good selection of properties available, for instance:Wetherall cottages (http://www.wetheralcottag...), near to Great Salkeld and Tottergill farm (http://www.tottergill.co....) the end of the valley.
For B&B there is a wide range of choice from staying on a farm, such as Brow farm (http://www.browfarm.com) in Dufton to experiencing the luxury of Willowbeck lodge (http://www.willowbeck-lod...) Carlisle.